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Moreover, in H4IIE cells, a rat hepatoma cell line, that were stably transfected with the cDNA for the 2-oxoglutarate carrier, exhibited increased uptake of GSH and 2-oxoglutarate and were protected from cytotoxicity induced by hydrogen peroxide, methyl vinyl ketone, or cisplatin, demonstrating the protective function of increased mitochondrial GSH transport and mGSH levels in the liver (153)
The Womens Health Initiative study found no reduction in fractures with vitamin D3 400 IU plus calcium in postmenopausal women, while the VITAL trial showed no benefit of vitamin D3 2000 IU daily for fracture prevention in generally healthy adults
The convenience of consistent abdominal injection often outweighs theoretical benefits of local injection for this reason
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Fluorescence-based measurement of cystine uptake through xCT shows requirement for ROS detoxification in activated lymphocytes
This review summarizes the roles of ferroptosis and mitochondrial injury in the progression of DCM and explores the molecular mechanisms involved, with an emphasis on the interplay between these two processes
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